Want to increase your lean mass? Study reviews what controls muscle mass and scientists summarize their results in a visualization (see figure)
The balance between muscle growth and wasting in a variety of conditions. Muscle growth conditions largely signal through mammalian target of rapamycin (mTOR), whereas wasting has multiple triggers and molecular targets including nuclear factor kappa B (NF-κB), growth arrest and DNA damage-inducible 45 (Gadd45) and small mother of decapentaplegic (Smad)2/3. ATF4, activating transcription factor 4; DMD, Duchenne muscular dystrophy; FSH, facioscapulohumeral muscular dystrophy; HDAC, histone deacetylase; LGD, Limb-girdle muscular dystrophy; SARM, selective androgen receptor modulators; TWEAK, tumour necrosis factor superfamily 12.
www.suppversity.com | Sepulveda, P. V., Bush, E. D. and Baar, K. (2015), Pharmacology of manipulating lean body mass. Clinical and Experimental Pharmacology and Physiology, 42: 1–13. doi: 10.1111/1440-1681.12320
The balance between muscle growth and wasting in a variety of conditions. Muscle growth conditions largely signal through mammalian target of rapamycin (mTOR), whereas wasting has multiple triggers and molecular targets including nuclear factor kappa B (NF-κB), growth arrest and DNA damage-inducible 45 (Gadd45) and small mother of decapentaplegic (Smad)2/3. ATF4, activating transcription factor 4; DMD, Duchenne muscular dystrophy; FSH, facioscapulohumeral muscular dystrophy; HDAC, histone deacetylase; LGD, Limb-girdle muscular dystrophy; SARM, selective androgen receptor modulators; TWEAK, tumour necrosis factor superfamily 12.
www.suppversity.com | Sepulveda, P. V., Bush, E. D. and Baar, K. (2015), Pharmacology of manipulating lean body mass. Clinical and Experimental Pharmacology and Physiology, 42: 1–13. doi: 10.1111/1440-1681.12320
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