четверг, 29 января 2015 г.

Полураспады стероидов,сроки обнаружения метаболитов,калькулятор-конвертор.

 Hormone Unit Conversion Calculator
Normal/Average Testosterone Levels in Men by Age + Unit Conversion Calculator
Unit Conversion Concentration solution
NORMAL MALE & FEMALE REFERENCE LEVELS
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TESTOSTERONE, FREE
Free & Bioavailable Testosterone calculator
 Male:


14-15 years: 3-138 pg/mL
16-17 years: 38-173 pg/mL
18 years and older: 47-244 pg/mL

Tanner Stage IV: 35-169 pg/mL
Tanner Stage V: 41-239 pg/mL
Testosterone, Adult Male:
Male:

14-15 years: 33-585 ng/dL
16-17 years: 185-886 ng/dL
18-39 years: 300-1080 ng/dL
40-59 years: 300-890 ng/dL
60 years and older: 300-720 ng/dL
Tanner Stage IV: 165-854 ng/dL
Tanner Stage V: 194-783 ng/dL
TESTOSTERONE, BIOAVAILABLE
Males
< or =19 years: not established
20-29 years: 83-257 ng/dL
30-39 years: 72-235 ng/dL
40-49 years: 61-213 ng/dL
50-59 years: 50-190 ng/dL
60-69 years: 40-168 ng/dL
> or =70 years: not established
Females (non-oophorectomized)
< or =19 years: not established
20-50 years (on oral estrogen): 0.8-4.0 ng/dL
20-50 years (not on oral estrogen): 0.8-10 ng/dL
> 50 years: not established
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* Direct, Free Testosterone by Direct Analog/Radioimmunoassay (RIA)
* Testosterone Free by Ultrafiltration (UF)
 * Testosterone Free by Equilibrium Tracer Dialysis (ETD)


* Testosterone Free and Weakly Bound by Radioasssay (FWRA)

Male Reference Range - Test Type (20-29 year old male)
* 66-417 nanogram/dL FWRA
* 12.3-63% %FWRA
* 5-21 nanogram/dL UF or ETD
* 50-210 picogram/mL UF or ETD
* 1.0-2.7% % of free by UF or ETD

The Decline of Androgen Levels in Elderly Men and Its Clinical and Therapeutic Implications
 
 
Oral steroids Drug Active half-life


Anabolicum Vister (Quinbolone) - Active Life: less than 8-12 hours
Activella (Norethindrone Acetate) - 9 hours
Anadrol / Anapolan (Oxymetholone) - 8 to 9 hours
Anavar (Oxandrolone) - 9 hours
Orabolin (Ethylestrenol) - 3.3 hours
Halotestin (Fluoxymesterone) - 9.2 hours.
Dimethyltestosterone (Bolasterone/Myagen) - 6 hours
Dianabol (Methandrostenolone, Methandienone) - 4.5 to 6 hours
Methyltrienolone (MT/ M3/ Metribolone/ Oral tren) - 4 to 5 hours
Methasterone (Superdrol) - 8-12 hours
Methyltestosterone - 6-8 hours
Methylhydroxynandrolone (MOHN) - approx. 12 Hours
Oranabol (Oxymesterone) - 8-10 Hours
M1T (Methyl - 1 - Testosterone) - 5 hours
Sublingual Testosterone Cyclodextrin - 60-68 min
Winstrol (Stanozolol) - 9 hours (oral)
Tetrahydrogestrinone (The Clear / THG) - 24 to 48 hours
Turanabol ( 4-chlorodehydromethyltestosterone) - 16 hours
Proviron (Mesterolone) - 12 - 13 hours
Cheque Drops (Mibolerone) - 3.7 hours
Methenolone Acetate - around 3 hours

Depot steroids Drug Active half-life
Nandrolone Phenyl Propionate (NPP) - 5 days
Deca-Durabolin (Nandrolone Decanate) - 6 days
Dynabolan (Nandrolone Undecanoate) - 6-7 days
Anadur (Nandrolone Hexylphenylpropionate) - 6-8 days
Dimethylnandrolone (DMN) - about 4 hours
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Equipoise (Boldenone Undecylenate) - 14 days
Primobolan (Methenolone Enanthate) - 10.5 days
Methenolone Acetate (Injectable) - 4-5 days
Sustanon / Omnadren - 15 to 18 days
Winstrol (Stanozolol) - 24 hours (injectable)
Masterject (Masteron, Mastabol) (Drostanolone Propionate) - 1-2 days
Masterject (Masteron, Mastabol) (Drostanolone Enanthate) - 5-6 days
Stenbolone Acetate (Anatrofin) - 1-2 days
Methandriol Dipropionate - 1-2 days
 
Finaplix/Finaject (Trenbolone Acetate) - 24-48 hours
Trenbolone Enanthate - 7-10 days
Trenbolone Cyclohexylmethylcarbonate - 14 days.
Parabolan (Trenbolone Hexahydrobenzylcarbonate) - 14 days.
 
Testosterone Buciclate - 29.5 days (+/- 3.9 days)
Testosterone Undecanoate (Nebido) - 18.3(+-2.3) - 23.7 (+-2.7)
Testosterone Cypionate - around 8 days
Testosterone Enanthate - around 5-7 days
Testosterone Phenylpropionate - 2-3 days (active life 4-5 days)
Testosterone Propionate - 0.8-1.5 days (active life 3.5 days)
Testosterone Suspension - 2 peaks (immediately hits the blood stream when injected and then a few days later the solid particles are slowly absorbed by the body)
Agovirin Depot (Testosterone Isobutyrate) -12 to 15 Days
Dihydrotestosterone - 7 days


 


  Ancillaries /Fat Burners Drug Active half-life


PI
Pramipexole Dihydrochloride (Mirapex, Mirapexin, Sifrol) - about 8 hours
Dostinex (Cabergoline) - between 63 to 69 hours
Parlodel (Bromocriptine Mesylate) - about 15 hours


AI
Arimidex (Anastrozole) - 30-46 hours
Femara (Letrozole) - 2-4 days
Aromasin (Exemestane) - about 24-27 hours
Cytadren (Aminoglutethimide) - 12.5 ± 1.6 hours.

An overview of the pharmacology and pharmacokinetics of the newer generation aromatase inhibitors anastrozole, letrozole, and exemestane

AE
Clomid (Clomiphene Citrate) - 5-7 days
Nolvadex (Tamoxifen Citrate) - 5-7 days
FARESTON® (Toremifene citrate) - 5 days
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 Fat Burners 
Albuterol (Salbutamol) - 2.85 (+/- 0.83) - 2.00 (+/- 0.49) hours
Clenbuterol - 36-48 hours
Ephedrine Hydrochloride - 3-6 hours
T3 (Triiodothyronine/Liothyronine Sodium) - 10 hours
T4 (Levothyroxine sodium/ L-thyroxine) - 7 days
Yohimbine Hydrochloride - 36 min

Other

Accutane (Isotretinoin) - 15-23 hours (acne)
VIAGRA (Sildenafil) - about 4 hours (erectile dysfunction
Tadalafil (Cialis) - 17.5 hours (erectile dysfunction)
Valium (Diazepam) - 1-3 hours (up to the age) / peak 1-1.5 hours
Lasix (Furosemide) - approximately 2 hours
 
 


 Steroid Remaining After Ester is Removed
100mg Testosterone Suspension (un-esterified Testosterone) = 100mg Testosterone
 100mg Testosterone Acetate = 87.28mg Testosterone (288.4244/330.4611=0.872793802356)
100mg Testosterone Propionate = 83.72mg Testosterone (288.4244/344.4877=0.8372560181)
100mg Testosterone Isobutyrate = 80.45mg Testosterone (288.4244/358.5143 =0.8044990)
100mg Testosterone Pentanoate = 77.42mg Testosterone (288.4244/372.5408=0.774208892)
100mg Testosterone Trimethylacetate = 77.42mg Testosterone (288.4244/372.5408=0.7742)
100mg Testosterone Isocaproate = 74.61mg Testosterone (288.4244/386.5674=0.746116718)
100mg Testosterone Hemisuccinate = 74.24mg Testosterone (288.4244/388.4972 =0.74241)
100mg Testosterone Benzoate = 73.47mg Testosterone (288.4244/392.5305=0.7347821379)
100mg Testosterone Dichloroacetate = 72.22mg Testosterone (288.4244/399.3512=0.72223)
100mg Testosterone Enanthate = 71.99mg Testosterone (288.4244/400.5940=0.719991812)
100mg Testosterone Cypionate = 69.9mg Testosterone (288.4244/412.6047=0.6990332393)
100mg Testosterone Caprylate = 69.56mg Testosterone (288.4244/414.6206=0.695634515)
100mg Testosterone Phenylpropionate = 68.57mg Testosterone (288.4244/420.5836=0.6857)
100mg Testosterone-3-Phenylpropionate = 68.25mg Testost-e(288.4244/422.5995=0.6825)
100mg Testosterone Tosylate = 65.16mg Testosterone (288.4244/442.6108=0.65164338511)
100mg Testosterone Decanoate = 65.15mg Testosterone (288.4244/442.6737=0.651550792)
100mg Testosterone Undecanoate = 65.15mg Testosterone (288.4244/ 456.7003=0.651550)
100mg Testosterone Dodecanoate = 61.27mg Testosterone (288.4244/470.7269=0.6127213)

100mg Trenbolone Acetate = 86.54mg Trenbolone (270.37/312.4028)
100mg Trenbolone Enanthate = 70.68mg Trenbolone (270.37/382.5357)
100mg Trenbolone Hexahydrobenzylcarbonate = 65.85 mg Trenbolone (270.37/410.54)

100mg Nandrolone Acetate = 86.71mg Nandrolone (274.3978/316.4345 =0.867155130050)
100mg Nandrolone Propionate = 83mg Nandrolone (274.3978/ 330.4611 = 0.830348261868)
100mg Nandrolone Hemisuccinate = 72.88mg Nandrolone (274.3978/ 376.4865 =0.72883)
100mg Nandrolone Benzoate = 72.5mg Nandrolone (274.3978/ 378.5039 = 0.7249536926)
100mg Nandrolone Enanthate= 70.98mg Nandrolone (274.3978/ 386.5674 =0.7098317136)
100mg Nandrolone Cypionate = 68.84mg Nandrolone (274.3978/ 398.5781 = 0.688441738)
100mg Nandrolone Caprylate = 68.49mg Nandrolone (274.3978/ 400.5940 =0.684977308)
100mg Nandrolone Phenylpropionate = 67.49mg Nandrolone (274.3978/ 406.5571 = 0.674)
100mg Nandrolone Decanoate = 64mg Nandrolone (274.3978/428.6472 =0.640148355104)
100mg Nandrolone Undecanoate = 61.98mg Nandrolone (274.3978/ 442.6737 = 0.6198646)
100mg Nandrolone Dodecanoate = 60mg Nandrolone (274.3978/456.7003 = 0.600826844)
100mg Nandrolone P-Hexyloxyphenylpropionate = 54.15mg Nandrolone (274.3978/506.7159= 0.5415)


 
100mg Drostanolone Propionate = 84.45mg Drostanolone (304.4669/360.5301=0.844497)
100mg Drostanolone Enanthate = 73mg Drostanolone (304.4669/416.6365 = 0.7307734679)

100mg Boldenone Acetate = 87.20mg Boldenone (286.4085/328.4452 = 0.872013048143191)
100mg Boldenone Hemisuccinate = 74.1mg Boldenone (286.4085/386.4813 = 0.74106690)
100mg Boldenone Benzoate = 73.34mg Boldenone (286.4085/390.5146 = 0.7334130401270)
100mg Boldenone Hexahydrobenzoate = 72.22mg Boldenone (286.4085/ 396.5622 = 0.7222)
100mg Boldenone Undecylenate = 63.27mg Boldenone (286.4085/452.6686=0.6327112152)
100mg Boldenone Undecanoate = 62.99mg Boldenone (286.4085/ 454.6844 = 0.62990615)

100mg Methenolone Acetate = 87.8 mg Methenolone (302.4558/344.49=0.87798)
100mg Methenolone Enanthate = 72.95mg Methenolone (302.4558/414.6206 = 0.72947605)
 
 
ПОЧЕМУ НЕ СТОИТ ПРИНИМАТЬ ТАМОКСИФЕН ПОСЛЕ НАДРОЛОНОВ и ТРЕБОЛОНОВ:
One must understand above everything that Nandrolone lacks the 19th carbon that Testosterone possesses, which makes it a Progestin and it has been demonstrated that 19-nor anabolic steroids tend to exhibit binding affinity for the Progesterone receptors in the body[1]. As mentioned above, this presents some issues that are not commonly seen with other anabolic steroids that are not Progestins. Nandrolone is considered to possess moderate Progestogenic activity. Progestogenic side effects are almost identical to Estrogenic side effects, and they include: severe endogenous Testosterone production shutdown/suppression, gynecomastia, and water retention. It has been discovered that the activity of Progestins is closely correlated with the activity of Estrogen in the body. There also exist some side effects associated with Progestins that are not seen in other anabolic steroids.
 
 19-nors being Progestogenic compounds are known to increase a hormone in the body known as Prolactin. Prolactin levels above normal in men often results in side effects such as lactating nipples, erectile dysfunction, anorgasmia (inability to achieve orgasm) and endogenous Testosterone production suppression/shutdown. An interesting point to learn is the fact that Progesterone itself is known to inhibit Prolactin production, and that 19-nors such as Nandrolone and Trenbolone being classified as Progestins should serve to actually suppress Prolactin levels. However, this is not the case as Nandrolone and Trenbolone are not Progesterone themselves – they are anabolic steroids that exhibit Progestogenic activity due to their chemical modifications and it is therefore very possible for these hormones to exhibit activity that is contrary to the activity of a similar hormone or parent hormone. It has been found that Nandrolone and Trenbolone can and do in fact increase Prolactin levels in the body.


 

Differences between aromatase inhibitors and tamoxifen are also apparent in changes in steroid hormone expression. Thus, immuno-staining for progesterone receptor (PgR) is reduced in almost all cases by aromatase inhibitors, becoming undetectable in many. This contrasts with effects of tamoxifen in which the most common change on PgR is to increase expression. Changes in proliferation occur rapidly following the onset of exposure to aromatase inhibitors.

 


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ВНИМАТЕЛЬНО НА КУРСЕ !!!
DAA​
Почему нельзя DAA после препаратов с 19-nor compound
The role of D-aspartic acid and N-methyl-D-aspartic acid in the regulation of prolactin release.
Part A – Simple Regression Analysis
Accumulation of D-Aspartic Acid (and NMDA) in the Adenohypophysis (Anterior Pituitary) causes increases in the secretion rates of Gonadotropin releasing hormone (GnRH), Growth-Hormone releasing hormone (GHRH), and Prolactin Releasing Factors (PRFs) which cause releases of Luteinizing hormone (LH) and Follicle-Stimulating Hormone (FSH), Growth Hormone (GH), and Prolactin, respectively.[21]
 


DHEA
DHEA increases estrogen levels in the body.​
Men given 100 mg of DHEA in capsule form experienced an undesirable increase in estrogen, and men taking more than 50 mg of DHEA daily in capsule form should have their estrogen levels monitored on a regular basis. Surprisingly, there was no increase of estrogen in the women using DHEA at 50 or 100 mg, however women did have an increase in testosterone androgens at this level.
 
Be cautious with this combination.
 Anastrozole (Arimidex)
 The body changes DHEA to estrogen in the body. Anastrozole (Arimidex) is used to help lower estrogen levels in the body. Taking DHEA along with anastrozole (Arimidex) might decrease the effectiveness of anastrozole (Arimidex). Do not take DHEA if you are taking anastrozole (Arimidex).
Exemestane (Aromasin)
 The body changes DHEA to estrogen in the body. Exemestane (Aromasin) is used to help decrease estrogen in the body. Taking DHEA along with exemestane (Aromasin) might decrease the effectiveness of exemestane (Aromasin). Do not take DHEA if you are taking exemestane (Aromasin).
Fulvestrant (Faslodex)
 Some types of cancer are affected by hormones in the body. Estrogen-sensitive cancers are cancers that are affected by estrogen levels in the body. Fulvestrant (Faslodex) is used for this type of cancer. DHEA might increase estrogen in the body and decrease the effectiveness of fulvestrant (Faslodex) for treating cancer. Do not take DHEA if you are taking fulvestrant (Faslodex).
Insulin
 Insulin is used to lower blood sugar. Insulin can also lower the amount of DHEA in the body. By lowering DHEA in the body, insulin might lower the effectiveness of DHEA supplements.
Letrozole (Femara)
 Some types of cancer are affected by hormones in the body. Estrogen-sensitive cancers are cancers that are affected by estrogen levels in the body. Letrozole (Femara) is used for this type of cancer. DHEA might increase estrogen in the body and decrease the effectiveness of letrozole (Femara) for treating cancer. Do not take DHEA if you are taking letrozole (Femara).
Tamoxifen (Nolvadex)
 Some types of cancer are affected by hormones in the body. Estrogen-sensitive cancers are cancers that are affected by estrogen levels in the body. Tamoxifen (Nolvadex) is used to help treat and prevent these types of cancer. DHEA increases estrogen levels in the body. By increasing estrogen in the body, DHEA might decrease the effectiveness of tamoxifen (Nolvadex). Do not take DHEA if you are taking tamoxifen (Nolvadex).
Triazolam (Halcion)
 The body breaks down triazolam (Halcion) to get rid of it. DHEA might decrease how quickly the body breaks down triazolam (Halcion). Taking DHEA along with triazolam (Halcion) might increase the effects and side effects of triazolam (Halcion).
 


GUGGUL​
Major Interaction Do not take this combination
•Estrogens interacts with GUGGUL
 Large amounts of guggul might theoretically increase the side effects of estrogen.
 Some estrogen pills include conjugated equine estrogens (Premarin), ethinyl estradiol, estradiol, and others.
 


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