Green Coffee Bean extract makes weight loss diet more effective

Supplementation with an extract made from unroasted coffee beans – Green Coffee Bean Extract as it’s called – can help overweight people who are on a diet to lose extra weight. Researchers at the University of Scranton write about this in a human study, published in Diabetes, Metabolic Syndrome and Obesity. Sounds good, but we don’t entirely trust the research.
Supplementation with an extract made from unroasted coffee beans – Green Coffee Bean Extract as it’s called – can help overweight people who are on a diet to lose extra weight. Researchers at the University of Scranton write about this in a human study, published in Diabetes, Metabolic Syndrome and Obesity. Sounds good, but we don’t entirely trust the research.

Coffee beans are bursting with chlorogenic acid analogues. Chlorogenic acid is created by adding caffeic acid to quinic acid.

Green coffee beans contain a number of chlorogenic acid analogues. When coffee is roasted lots of these analogues are lost. Nevertheless big coffee drinkers can ingest up to a gram or more of chlorogenic acid analogues daily.

Extracts containing chlorogenic acid analogues have been on the market for years. They are found in diet products. One of these extracts is GCA, made by Applied Food Sciences. It consists of 46 percent chlorogenic acid analogues and 2-4 percent caffeine.

Although there’s no mention in the publication, the study that has appeared in Diabetes, Metabolic Syndrome and Obesity was funded by Applied Food Sciences. The research was carried out in India.

Sixteen fairly overweight people aged between 22 and 46 participated in the 22-week-long study. This consisted of three six-week phases, in which the subjects were given a placebo [PL], 700 mg Green Coffee Bean Extract [LD], or 1050 mg Green Coffee Bean Extract [HD] daily. During each phase there was a wash-out period of two weeks during which the subjects took nothing [WO].

The figure below shows that during the phases when the subjects took a placebo little or nothing happened. During the phases that the subjects took Green Coffee Bean Extract they lost weight.

After one six-week placebo treatment, one six-week period of taking 700 mg Green Coffee Bean Extract, one six-week period of taking 1050 mg Green Coffee Bean Extract and two two-week wash-out periods the subjects lost 8.1 kg in bodyweight.

An eight-kilogram weight loss – about 5.3 kg fat and 2.8 kg lean body mass – in 22 weeks is a pretty impressive result. A bit too good, for a supplement. But after bit of googling we discovered that the results were not due to supplementation alone.

During the study the subjects ate 2400 kcal per day. It’s not mentioned in the study but the subjects also burned more than 400 kcal per day through exercise. Dietician Diane Kress reports this in her blog, quoting the lead author of the study, Joe Vinson. [thewhistleblog.blogspot.com/2012/07]

“Please note that 2400 calories/day with a 400 calorie exercise burn is not a typical intake for an obese adult”, Kress writes. “A 2400 calorie dietary intake with 400 calories of exercise burn is typically a weight loss diet for an obese adult.”

Randomized, double-blind, placebo-controlled, linear dose, crossover study to evaluate the efficacy and safety of a green coffee bean extract in overweight subjects.

Vinson JA, Burnham BR, Nagendran MV.

Source

Chemistry Department, University of Scranton, Scranton, PA, USA.

Abstract

BACKGROUND:

Adult weight gain and obesity have become worldwide problems. Issues of cost and potential side effects of prescription weight loss drugs have led overweight and obese adults to try nutraceuticals that may aid weight loss. One promising nutraceutical is green coffee extract, which contains high concentrations of chlorogenic acids that are known to have health benefits and to influence glucose and fat metabolism. A 22-week crossover study was conducted to examine the efficacy and safety of a commercial green coffee extract product GCA™ at reducing weight and body mass in 16 overweight adults.
METHODS:

Subjects received high-dose GCA (1050 mg), low-dose GCA (700 mg), or placebo in separate six-week treatment periods followed by two-week washout periods to reduce any influence of preceding treatment. Treatments were counterbalanced between subjects. Primary measurements were body weight, body mass index, and percent body fat. Heart rate and blood pressure were also measured.
RESULTS:

Significant reductions were observed in body weight (-8.04 ± 2.31 kg), body mass index (-2.92 ± 0.85 kg/m(2)), and percent body fat (-4.44% ± 2.00%), as well as a small decrease in heart rate (-2.56 ± 2.85 beats per minute), but with no significant changes to diet over the course of the study. Importantly, the decreases occurred when subjects were taking GCA. Body mass index for six subjects shifted from preobesity to the normal weight range (<25.00 kg/m(2)).
CONCLUSION:

The results are consistent with human and animal studies and a meta-analysis of the efficacy of green coffee extract in weight loss. The results suggest that GCA may be an effective nutraceutical in reducing weight in preobese adults, and may be an inexpensive means of preventing obesity in overweight adults.
KEYWORDS:

blood pressure, body fat mass, body mass index, chlorogenic acid, green coffee bean extract, heart rate, weight loss

PMID: 22291473 [PubMed] PMCID: PMC3267522

Source: http://www.ncbi.nlm.nih.gov/pubmed/22291473